THESIAS - Testing Haplotype Effects In Association Studies
The objectif of the THESIAS program is to performed haplotype-based association
analysis in unrelated individuals. This program is based on the maximum
likelihood model described in Tregouet et al. 2002 (Hum Mol Genet 2002,11:
2015-2023) and is linked to the SEM algorithm (Tregouet et al. Ann Hum Genet
2004,68: 165-177). THESIAS allows one to simultaneous estimate haplotype
frequencies and their associate effects on the phenotype of interest. In this
new THESIAS release, quantitative, qualitative (logistic and matched-pair
analysis), categorical and survival outcomes can be studied. X-linked
haplotype analysis is also feasible. Covariate-adjusted haplotype effects as
well as haplotype x covariate interactions can also be investigated.
THESIAS was written by David-Alexandre Trégouët.